About Tumor Marker Blood Tests

Tumor Marker Blood Tests (By Organ/System)

1. Digestive Tract (Gastrointestinal):

  • CEA (Carcinoembryonic Antigen):
    A general tumor marker often elevated in cancers of the colon, rectum, and other parts of the digestive tract. Also used to monitor treatment and recurrence.
  • CA19-9 (Carbohydrate Antigen 19-9):
    Commonly used to detect pancreatic and biliary tract cancers, and may also rise in gastrointestinal cancers.

2.Lungs:

  • CYFRA (Cytokeratin 19 Fragment):
    A marker often elevated in non-small cell lung cancer, especially squamous cell carcinoma.
  • ProGRP (Pro-Gastrin-Releasing Peptide):
    A specific marker for small cell lung cancer (SCLC), helpful in both diagnosis and monitoring.

3.Pancreas:

  • Span-1:
    A tumor marker associated with pancreatic cancer. Often used in combination with other tests like CA19-9 for better accuracy.
  • Elastase (Pancreatic Elastase):
    A digestive enzyme whose blood levels can rise in pancreatic disorders, including cancer.

4.Liver:

  • AFP (Alpha-Fetoprotein):
    Commonly used to detect liver cancer (especially hepatocellular carcinoma) and to monitor patients with chronic liver disease.
  • PIVKA-II (Protein Induced by Vitamin K Absence or Antagonist-II):
    A highly specific marker for hepatocellular carcinoma, often used alongside AFP for better sensitivity.

Gender-Specific Tumor Markers

For Men:

  • PSA (Prostate-Specific Antigen):
    A widely used marker to detect and monitor prostate cancer. High levels may also indicate benign prostate conditions.

For Women:

  • CA-125 (Cancer Antigen 125):
    Often elevated in ovarian cancer. Also may increase in other gynecologic or abdominal conditions.
  • NCC-ST-439:
    Also known as STn (Sialyl-Tn Antigen), used as a marker in breast and gynecologic cancers.